Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition.
نویسنده
چکیده
The role of static structure and conformational flexibility in the recognition of RNA targets by small molecule ligands is discussed with emphasis on the natural aminoglycoside antibiotics and their promiscuity in RNA target binding. A brief overview is given of previous efforts to design simplified aminoglycoside derivatives targeted at the bacterial decoding site RNA.
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ورودعنوان ژورنال:
- Biochimie
دوره 84 9 شماره
صفحات -
تاریخ انتشار 2002